Neurobeachin regulates transmitter receptor trafficking to synapses
نویسندگان
چکیده
1 Departments of Functional Genomics and Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU) and VU Medical Center, 1081 HV Amsterdam, Netherlands 2 Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany 3 Department of Genetics and Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA 4 Department of Neuroscience, Uppsala University, 75124 Uppsala, Sweden
منابع مشابه
Neurobeachin regulates neurotransmitter receptor trafficking to synapses
The surface density of neurotransmitter receptors at synapses is a key determinant of synaptic efficacy. Synaptic receptor accumulation is regulated by the transport, postsynaptic anchoring, and turnover of receptors, involving multiple trafficking, sorting, motor, and scaffold proteins. We found that neurons lacking the BEACH (beige-Chediak/Higashi) domain protein Neurobeachin (Nbea) had stron...
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